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In short, radical species can attack most biological substrates from large macromolecules to smaller molecules such as catechols. Exceptionally, stable radical species can be formed, mostly due to steric protection of the unpaired electron.

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Examples include the melanins (72-75)and the stable radical derivatives produced in spin-trapping measurements.(7,28)

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Cerovive is a registered trademark of the astrazeneca company for the disulfate derivative of PBN or phenylbutylnitrone. Go to the link above for more details. Cerovive is currently in Phase-3 trials for stroke.

This compound is also called nxy-059. The Renovis company is currently undergoing an ipo ( initial public offering ). Recently, Renovis bought the intellectual property of Centaur Pharmaceuticals. This includes nominal claims to cerovive.

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